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Demographics of infertility and management of unexplained infertility

Mohan S. Kamath MS, DNB and Siladitya Bhattacharya MD, FRCOG

Published online Jun-2013, pages 729 - 738


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Introduction

Infertility has been defined as failure to conceive after regular unprotected sexual intercourse for 1 year.1 and 2 x The Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss. Fertil Steril. 2008;90(5 Suppl.):S60 x S. Gurunath, Z. Pandian, R.A. Anderson, et al. Defining infertility: a systematic review of prevalence studies. Hum Reprod Update. 2011;17:575-588 Crossref. This definition reflects the prognostic approach to this condition, based on the knowledge that, in a general population, 84% of all women are expected to conceive within 1 year of regular unprotected sexual intercourse. This figure rises to 92% after 2 years, and 93% after 3 years.3 x E.R. te Velde, R. Eijkemans, H.D. Habbema. Variation in couple fecundity and time to pregnancy, an essential concept in human reproduction. Lancet. 2000;355:1928-1929 Crossref. The term ‘unexplained infertility’ refers to infertile couples in whom standard investigations, including tests of ovulation, tubal patency and semen analysis, are normal. The prevalence of unexplained infertility has been shown to vary from 22–28%.4 and 5 x J.A. Collins, T.C. Rowe. Age of the female partner is a prognostic factor in prolonged unexplained infertility: a multicentre study. Fertil Steril. 1989;52:15-20 x M.G. Hull, C.M. Glazener, N.J. Kelly, et al. Population study of causes, treatment, and outcome of infertility. Br Med J (Clin Res Ed). 1985;291:1693-1697 Crossref. A more recent study puts the prevalence among couples attending a fertility clinic to be 21% in women aged under 35 years, and 26% in women over 35 years.6 x A. Maheshwari, M. Hamilton, S. Bhattacharya. Effect of female age on the diagnostic categories of infertility. Hum Reprod. 2008;23:538-542 Crossref.

References

Label Authors Title Source Year
3

References in context

  • This figure rises to 92% after 2 years, and 93% after 3 years.3 The term ‘unexplained infertility’ refers to infertile couples in whom standard investigations, including tests of ovulation, tubal patency and semen analysis, are normal.
    Go to context

E.R. te Velde, R. Eijkemans, H.D. Habbema Variation in couple fecundity and time to pregnancy, an essential concept in human reproduction Crossref. Lancet. 2000;355:1928-1929 2000
6

References in context

  • Infertility has been defined as failure to conceive after regular unprotected sexual intercourse for 1 year.1,2 This definition reflects the prognostic approach to this condition, based on the knowledge that, in a general population, 84% of all women are expected to conceive within 1 year of regular unprotected sexual intercourse.
    Go to context

A. Maheshwari, M. Hamilton, S. Bhattacharya Effect of female age on the diagnostic categories of infertility Crossref. Hum Reprod. 2008;23:538-542 2008

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